UTHSC
Drosophila Transgenic Core
The Molecular Resource Center is proud to announce the Drosophila melanogaster transgenic core facility (DTC) in the department of Neurology at the University of Tennessee Health Science Center. This facility will be the first of its kind in the Memphis area and will further enhance genetic approaches to translational research at UTHSC. The purpose of the Drosophila Transgenic Core (DTC) is to encourage investigator’s to utilize the genetic screening tools in Drosophila to quickly identify genetic pathways or individual genes related to their disease gene of interest. The primary tools of the DTC will be the construction of transgenic Drosophila lines containing the investigator’s gene of interest under the control of the yeast upstream activator sequence (UAS). We can assist these investigators in generating visible phenotypes in the eye, wing, larvae or other tissues using various GAL4 drivers maintained in the lab. Using the Drosophila deletion kits (both Bloomington and DrosDel collections) we will help train individuals from the investigator’s laboratory to screen for potential suppressors or enhancers of the phenotypes generated. Additional projects can also be performed on a case-by-case basis, such as the creation of lines for proteomic analysis, single neuron mutation analysis or phenotypic analysis of mutants.
Two years work wasted, I have been breeding those flies for all that time and I've got nothing out of it.
- Thomas Hunt Morgan
The UTHSC Drosophila Transgenic Core
